Cardiospam® Clinical Pharmacology

 

Cardiospam® (Coenzyme Q10 200mg + Lecithin 200mg) Capsules

Cardiospam® is an an oral therapy for support of the heart muscle.

Cardiospam® combines high quality herb and ubiquinones, Coenzyme Q10 and Lecithin to help in the support cardio functions.

The pharmacology of its principal ingredients are.

 

 

Coenzyme Q10

ACTIONS

CoQ10 may help cardioprotective, cytoprotective and neuroprotective activities.

MECHANISM OF ACTION

Since the actions of supplemental CoQ10 have yet to be clarified, the mechanism of this actions is a matter of speculation. However, much is know about the biochemistry of CoQ10. CoQ10 is an essential cofactor in the mitochondrial electron transport chain., where it accepts electrons from complex 1 and II, an activity that is vital for the production of ATP.

CoQ10 has an antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.

CoQ10 is biosynthesizes in the body and shares a common synthetic pathway with cholesterol. CoQ10 levels decrease with aging in humans. Why this occurs is not know but may be due to decreased synthesis and/or lipid peroxidation which occurs with aging.

PARMACOKINETICS

CoQ10 is absorbed from the small intestine into the lymphatics, from there it enters the blood torrent. Absorption of CoQ10 is poor. Well over 60% of an oral dose is excreted in the feces. Furthermore, absorption of CoQ10 is highly variable and depends not only on food intake but also on the amount of lipids present in the food. Absorption is lower on an empty stomach and greater when taken with food of high lipid content. In the blood , CoQ10 is partitioned into the various lipoproteins, including VLDL, LDL, and HDL.

It takes about three weeks of daily dosing with CoQ10 to reach maximum serum concentration, which then plateau with continuous daily dosing and is able to enter the brain. The main elimination of CoQ10 occurs via bile.

Lecithin

Lecithin is a lipid that consists mostly of choline, but also includes inositol, phosphorus, and linoleic acid. Lecithin helps to prevent arteriosclerosis, protects against cardiovascular disease, improves brain function, helps keep the liver and kidneys healthy, aids in thiamin and vitamin A absorption, and can even help to repair liver damage caused by alcoholism--this nutrient is essential to every living cell in the human body. The choline and inositol in lecithin protect against hardening of the arteries and heart disease by promoting normal processing of fat and cholesterol. Lecithin itself helps to bind fats and cholesterol to water so that they can pass through the body rather than cause a potentially harmful buildup in the heart or liver. Cell membranes, the protective sheaths surrounding the brain, and nerve cells also contain this essential fatty substance.

Lecithin is an emulsifying agent, meaning that it is able to suspend the fat and cholesterol that is traveling through the bloodstream and stop it from attaching to the artery walls, thus preventing atherosclerosis.

Lecithin protects your heart health by preventing cholesterol and other fats from accumulating on the walls of your arteries. In addition, lecithin performs vital functions in the liver, intestines, skin, nervous system and more.

Hypercholesterolemia

Lecithin seems to possess beneficial properties in reducing cholesterol levels and controlling or preventing atherosclerosis. However, studies done in the late 1970's to early 1980's provide insufficient clinical or epidemiologic evidence to entirely support its positive effects against atherosclerosis. Although other studies from this time appear promising and have found results such as “18% cholesterol reduction,” or “lowered cholesterol levels along with changes in lipid metabolism,” no study was definitive with respect to atherosclerosis progression.

 

Clinical data

Four months of soybean lecithin administration was found to reduce total serum lipids, cholesterol, and triglycerides in 21 hyperlipidemic patients.1The mechanism appears to be enhancement of cholesterol metabolism in the digestive system.

references:

1. Saba P, et al. Current Therapeutic Research, Clinical & Experimental . 1978 Aug;24:299-306.