BOTICA ESPECIALIZADA EN FÓRMULAS MAGISTRALES

Prueba de Magnesio

Prueba de celulas bocales - Bucal Smear Test (EXA Test)

Es un prueba la cual se hace en el consultorio tomando una muestra de las células epiteliales planas de la mucosa bucal y sublinguales. Esta prueba es enviada a Intracellular Diagnostics en los Estados Unidos para su diagnosticó técnico. La razón de usar estas cedulas para la prueba de magnesio es que el magnesio está en las células y tejidos como el corazón. Las células epiteliales planas de la mucosa bucal y sublingual se correlacionan bien con el tejido corporal profunda como tejido cardíaco.

Por que muestras bocales

1. La investigación ha demostrado que las células epiteliales se correlacionan bien sublinguales
con el tejido corporal profunda como tejido cardíaco tomada durante la cirugía de derivación y
biopsias de músculo esquelético. Además, los estudios de la NASA de los cambios musculares y huesos
en el espacio correlacionar con las células epiteliales sublinguales.

2. Células bucales tienen una alta correlación entre el mineral alterado
niveles y condiciones fisiopatológicas en múltiples síndromes médicos.

3. Células sublinguales proporcionan una nueva e importante información sobre el estado
de los electrolitos minerales cardíacos en pacientes con enfermedad cardiovascular.

4. Células epiteliales sublinguales ofrecen una rápida renovación, celular homogénea
población que refleja el estado mineral intracelular corporal total actual.

5. Células bucales tienen un alto citoplasma al núcleo de la estructura para facilitar mineral
análisis. Las células contienen vías bioquímicas metabólicas completas.

6. Los niveles en sangre y orina de los minerales y los iones no necesariamente reflejan lo
que ocurre en los tejidos celulares de trabajo.

7. Células de los tejidos contienen 99% o más de magnesio y de potasio del cuerpo, mientras que el suero
contiene sólo el 1% del total.

Referencias:

1. Noninvasive Measurement of Tissue Magnesium and Correlation With Cardiac Levels, (Full Text). Mark C.P. Haigney, MD; Burton Silver, PhD; Emmanuel Tanglao, MD; Howard S. Silverman, MD; J. Donald Hill, MD; Edward Shapiro, MD; Gary Gerstenblith, MD; Steven P. Schulman, MD; Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions; IntraCellular Diagnostics, Inc., Circulation, 1995; 92: 2190-2197.

 2. Noninvasive Measurement of Tissue Magnesium and Correlation With Cardiac Levels, (Abstract)MCP Haigney, B Silver, E.Tanglao, HS Silverman, JD Hill, E Shapiro, G Gerstenblith, SP Schulman, Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, IntraCellular Diagnostics, Inc., Circulation, 1995; 92: 2190-2197.

3. Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease, (Abstract). Michael Shechter, MD, MA; Michael Sharir, MD; Maura J. Paul Labrador, MPH; James Forrester,MD;  Burton Silver, PhD;  C. Noel Bairey Merz, MD; Cedars-Sinai Burns and Allen Research Institute, the Division of Cardiology, Department of Medicine,  Cedars- Sinai Medical Center,  UCLA School of Medicine and IntraCellular Diagnostics, Inc, Circulation 2000;102: 2353-2358.

4. Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease, (Full Text). Michael Shechter, MD, MA; Michael Sharir, MD; Maura J. Paul Labrador, MPH; James Forrester,MD;  Burton Silver, PhD;  C. Noel Bairey Merz, MD; Cedars-Sinai Burns and Allen Research Institute, the Division of Cardiology, Department of Medicine,  Cedars- Sinai Medical Center,  UCLA School of Medicine and IntraCellular Diagnostics, Inc., Circulation 2000;102: 2353-2358.

5. Magnesium Modulation of Calcium Uptake in Cardiac Mitochondria: An Ultrastructual Study. B.B. Silver, L.A. Sordahl; Spectrum Publications, Inc., Magnesium in Health and Disease, pp.508-513, 1980.

6. Tissue Magnesium Levels and the Arrhythmic Substrate in Humans  (Abstract). 
Haigney MC, Berger R, Schulman S, Gerstenblith G, Tunin C, SilverB, Silverman HS, Tomaselli G, Calkins H; Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions; IntraCellular Diagnostics, Inc.; Journal of Cardiovascular Electrophysiology, Vol. 8, pp.980-986, Number 9. September 1997 .

7. Tissue Magnesium Levels and the Arrhythmic Substrate in Humans
(Full Text). Mark C.P. Haigney, MD; Ronald Berger, MD, PhD; Steven Schulman, MD; Gary Gerstenblith, MD; Carol Tunin, PhD; Burton Silver, PhD, Howard S. Silverman, MD; Gordon Tomaselli, MD; Hugh Calkins, MD; Department of Medicine, Division of Cardiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, Johns Hopkins Medical Institutions; IntraCellular Diagnostics, Inc.; Journal of Cardiovascular Electrophysiology. Volume 8. Number 9. September 1997.

8. Loss of Cardiac Magnesium in Experimental Heart Failure Prolongs and Destabilizes Repolarization, (Abstract). Haigney MC, Silver B, Wei S, Kaab S, Griffiths E, Berger R, Tunin R, Kass D, Fisher WG, Silverman H. Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, IntraCellular Diagnostics, Foster City, CA, J Am Coll Cardiol 1998 Mar 1;31(3):701-6.

9. Loss of Cardiac Magnesium in Experimental Heart Failure Prolongs and Destabilizes Repolarization, (Full Text). Haigney MC, Silver B, Wei S, Kaab S, Griffiths E, Berger R, Tunin R, Kass D, Fisher WG, Silverman H Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, IntraCellular Diagnostics, Inc. Foster City, CA 94404\Medford, Oregon: J Am Coll Cardiol 1998 Mar 1; 31(3): 701-6.

10. A Unique Non-Invasive Intracellular Magnesium Assay; Correlating with Cardiac Tissues, Arrhythmias, and Therapeutic Interventions. (REVIEW)
VII International Symposium on Magnesium, Athens, Greece, 1997, Burton B. Silver, Mark C.P.Haigney et al., Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, Uniformed Services University of the Health Sciences, Bethesda, MD, IntraCellular Diagnostics, Inc, Foster City, CA./Medford, Oregon.

11. Effects of Simulated Microgravity on Intracellular Ion Concentrations in Sublingual Cells and Skeletal Muscle,(Full Text). B.B. Silver, S.B. Arnaud, B.A Harris, and J Vernikos-Dannellis. IntraCellular Diagnostics Inc., Foster City, CA & NASA Ames Research Center, Moffet Field, CA 94035 Aerospace Medical Association, Washington D.C, 1989 .

12. Application of a Novel Method to Measure IntraCellular Ions as Applied to Space Flight.S.B. Arnaud & B. B. Silver, NASA Ames Research Center, Moffet Field, CA, 94035, IntraCellular Diagnostics, Inc, Foster City, CA, 94404, NASA Technology 2000 Proceedings, Washington, D.C. 1990.

13. Life Science in Space: Intracellular  Measurements of Calcium, Phosphorus Loss in Microgravity.S.B. Arnaud & B. B. Silver, NASA Ames Research Center, Moffet Field, CA, 94035, IntraCellular Diagnostics, Inc, Foster City, CA, 94404, NASA, Bone and Mineral Conference, Indianapolis, IN, 1987.

14. NASA –Russian Study :  Space Flight Effects on Intracellular Ions in Sublingual cells of Non-Human Primates. S.B. Arnaud, R. Dotsenko, P. Fung, M Navidi and B. Silver, Life Sciences Division, NASA Ames Research Center, CA 94035, Institute for Biomedical Problems, Moscow, Russia, and IntraCellular Diagnostics, Inc. Foster City, CA 94404, Aerospace Medical Association, 1994.

15. Might Patients with the Chronic Fatigue Syndrome Have Latent Tetany of Magnesium Deficiency, (Review). Mildred Seelig, MD, MPH Journal of Chronic Fatigue Syndrome, Vol. 4(2) 1998.

16. Dr. M. Haigney Lecture Notes on Arrhythmias, & Animated Link to Principles of Electro Cardiograms. 

17. Usefulness of Magnesium Sulfate in Stabilizing Cardiac Repolarization in Heart Failure Secondary to Ischemic Cardiomyopathy.
(Full Text). Carlos Ince,MD; Steven P. Schulman, MD; John F. Quigley,MA; Ronald D. Berger, MD; Mark Kolasa, MD; Renee Ferguson, CTT; Burton Silver, PhD; Mark C.P. Haigney; MD; The American Journal of Cardiology, Vol. 88 – Issue 3, August 1, 2001

18. EXA  Individual Report

19. EXA Individual Element Concentrations